Inflammatory colon disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. arthritis [2]. In fact, inflammatory bowel diseases (IBD), namely, Crohn’s ARHGEF11 disease (CD) and ulcerative colitis (UC), are among the most frequent extra-articular complications that may occur in patients with AS. From the gastroenterologist’s perspective, arthritis is the most frequent extraintestinal manifestation in IBD and may develop before, simultaneously with, or after the diagnosis of overt intestinal disease [3]. The prevalence of IBD in patients with AS is estimated between 5 and 10%, but nearly 50% of AS patients have subclinical gut inflammation [4]. From the point of view of IBD, 3% of the patients have concomitant AS and 13% have peripheral SpA according to a recent meta-analysis [5], but radiographic sacroiliitis, either symptomatic or subclinical, may involve half of the IBD patients [6]. The fact that joint symptoms may be mild or absent and the use of concomitant immunosuppressive therapies for IBD and the use of the New York criteria for AS may hamper the early diagnosis of SpA/IBD, resulting in a significant diagnostic delay, has been associated with several adverse outcomes for the patient, including poor quality of life and progression of joint damage [7, 8]. Proof from preclinical research corroborated the hypothesis that Health spa and IBD may talk SIBA about a common pathogenesis, as with both illnesses there can be an participation of tumor necrosis element (TNF-is popular and additional attested from the long connection with treatment with TNF inhibitors for both Health spa and IBD, medical tests of anti-IL17A real estate agents in IBD didn’t reach the principal endpoint as well as appear to possess a worsening influence on Compact disc [10]. Conversely, ustekinumab, the 1st IL-12/23 inhibitor, is currently approved for the treating Compact disc but didn’t improve signs or symptoms of axial Health spa [11]. Taken collectively, these differences claim that, regardless of the many features that IBD and Health spa have as a common factor, the coexistence of joint and gut inflammations is exclusive. This is additional suggested from the percentage SIBA of human being leukocyte antigen- (HLA-) B27-positive individuals in the axial Health spa/IBD group, less than AS and Health spa generally [3, 12, 13]. Furthermore, asymptomatic sacroiliitis, which exists in a substantial percentage of IBD individuals, is not connected with HLA-B27 [12]. Finally, the coexistence of gut and joint involvements advocates the multidisciplinary administration of Health spa/IBD individuals, like in another multifaceted Health spa like psoriatic joint disease [14]. Overall, Health spa/IBD could be not just SIBA a subset from the wide entities of IBD and Health spa but also a definite and rather peculiar disease asking for a tailored medical evaluation and restorative approach. For this accomplishment, recommendation strategies like the use of testing questionnaires [15] as well as the recognition of basic biomarkers are warranted. 2. WHAT EXACTLY ARE Biomarkers? A biomarker can be a characteristic that may be SIBA objectively assessed and examined as an sign of a standard biologic procedure, a pathophysiologic procedure, or a pharmacologic response to a restorative treatment [16]. Ideal biomarkers ought to be delicate, particular, reproducible, and derived from a noninvasive procedure. Each biomarker could theoretically be useful for the processes of diagnosis, treatment response, and prognosis evaluation, but such instruments are rare in clinical practice. A further differentiation should be made between molecular, imaging, and clinical biomarkers of disease. Molecular biomarkers are biochemical variables that can be.