Supplementary Materialscancers-12-01199-s001. rank collection test, and Duval and Tweedies trim and fill methods. Out of 2909 studies retrieved, 79 studies were shortlisted and reviewed. A total of 17 studies met our eligibility criteria, from which 779 PrC patients and 17 chemotherapy drugs were examined, including docetaxel and paclitaxel. The majority of the drug regulatory genes reported were involved in cell survival, angiogenesis and cell proliferation pathways. We studied 42 miRNAs across all studies, out of which two miRNAs were found to be influencing chemosensitivity, while 21 were involved in chemoresistance. However, the remaining 19 miRNAs did not appear to have any theragnostic effects. Besides, the prognostic impact of the miRNAs was evaluated and had a pooled HR value of 1 1.960 with 95% CI (1.377C2.791). The observation of the current study Mouse monoclonal to MCL-1 depicts the significance of miRNA expression as a theragnostic biomarker in medical oncology. This review suggests the involvement of specific miRNAs as predictors of chemoresistance and sensitivity in PrC. Hence, the current systematic review and meta-analysis provide insight on the use of miRNA as PrC biomarkers, which can be harnessed as molecular candidates for therapeutic targeting. = 179) and ScienceDirect (= 2730). After a thorough screening, 2830 articles were removed SKI-606 tyrosianse inhibitor for being duplicates, irrelevant, reviews, case studies and letters to the editor. Screening based on inclusion criteria was used to narrow down to 79 potentially eligible studies, and further screening based on exclusion criteria resulted in 17 articles. Physique 1 depicts a flowchart describing our selection process. Open in a separate window Physique 1 Flowchart of the literature study process and selection. We identified 17 studies involving 779 PrC patients eligible for the systematic review. Table 1 shows the main characteristics of the included studies for the systematic review and meta-analysis. The included studies were SKI-606 tyrosianse inhibitor conducted between 2005 and 2015. The majority of studies were performed in China (= 11) followed by USA (= 4) and one each from Australia and Austria. The two most preferred chemotherapy agents were docetaxel and paclitaxel. Table 1 Description of the 17 included studies. = 3.53225, df = 7. The one-tailed em p /em -value (recommended) is usually 0.00478, and the two-tailed em p /em -value is 0.00957. 3.7.6. Duval and Tweedies Trim and Fill This method suggests that three studies are missing (Physique 6). Under the fixed-effect model, the point estimate and 95% confidence interval for the combined studies are 1.86926 (1.54497, 2.26162). Using trim and fill, the imputed point estimate is usually 1.52342 (1.28781, 1.80214). SKI-606 tyrosianse inhibitor Under the random-effects model, the point estimate and 95% confidence interval for the combined studies are 1.99148 (1.31951, 3.00566). Using trim and fill, the imputed point estimate is usually 1.56458 (1.06512, 2.29825). Publication bias analysis of the included studies was conducted to study the effect of publication bias around the results of this study. Physique 6 shows the funnel plot results with imputed studies. The symmetric nature of the plot denotes the presence of no bias. From the funnel plot, it is obvious that the smaller included studies place towards the bottom of the funnel plot, and the more extensive studies look towards SKI-606 tyrosianse inhibitor the top of the graph, with clustering near the mean effect size. Large studies appear outside the funnel and tend to cluster on one side of the funnel plot. Smaller studies appear toward the top of the graph, since there is more sampling variation in effect size estimates in the smaller studies, which will be.