There is developing interest in the applications of diffusion-weighted-imaging (DWI) in oncologic area for last ten years. evaluated the contribution of DWI to differentiation of atypical/malignant and typical meningiomas. They demonstrated that atypical/malignant meningiomas had lower ADC values than typical meningiomas ((18) suggested that differentiation between low and high grade gliomas is possible using ADC measurement. Open in a separate window Figure 2 A 61-year-old man with glioblastoma multiforme proven histopathologically. (A) Contrast enhanced T1 weighted image shows heterogenous and irregular enhancement of the lesion; (B) The lesion has lower ADC value (0.610C3 mm2/s) than ADC value of the normal brain parenchyma (1.0210C3 mm2/s). Abbreviation: ADC, apparent-diffusion-coefficient. Metastasis is the most common intracranial tumor in adults. The most common metastasize to the brain are lung, breast, skin, genitourinary tract ((20) studied 21 patients with metastasis and have found a mean ADC value of 0.7810C3 mm2/s (used 1,000 s/mm2 gradient). ADC values of the metastasis were not statistically significant from glioblastomas. Duygulu (21) evaluated the 76 patients with intracerebral metastasis using DWI. ADC value in metastasis showing restricted diffusion was 0.7210C3 mm2/s (used 1,000 s/mm2 gradient). Open in a separate window Figure 3 A 60-year-old man with primary bladder cancer and brain metastasis. (A) FLAIR image shows right occipital metastasis and peritumoral vasogenic edema; (B) Color ADC map. ROI 1 shows the lesion and, ROI 2, 3 show normal parenchyma. ADC value of the metastasis was lower than ADC values of normal parenchyma. Abbreviations: ADC, apparent-diffusion-coefficient; ROI, region of interest. DWI has also important role in the evaluation of extracranial tumors such as Rabbit Polyclonal to URB1 thyroid (22), orbit and head and neck tumors (values. We concluded that DWI may be helpful in differentiating malignant and benign thyroid nodules (22) (value of 300) of benign (B) and malignant nodule (C) in the same level of axial T2 images, respectively. Malignant nodule has lower ADC values than benign nodule. ADC values of malignant and benign nodules are 0.210C3 and 1.7610C3 mm2/s, (25) reported that mean ADC value of hemangioma (used following values 3, 50 and 300) was 2.2310C3 mm2/s. Demir (27) mentioned that mean ADC value of hemangioma (used 1,000 s/mm2 gradient) was 2.4610C3 mm2/s. According to our study mean ADC value of 61 hemangiomas was 1.9810C3 mm2/s for 600) are 1.2610C3 and 1.8310C3 mm2/s. Abbreviations: ADC, apparent-diffusion-coefficient; ROI, region of interest. Hepatoma ((29) evaluated the ADC values for characterization of a variety of focal liver lesions. Mean ADC values (used (27) evaluated the diagnostic role of DWI in differentiation between benign and malignant liver lesions. Mean ADC values (used (31) characterized renal lesions using DWI. The mean ADC value (used 600 gradient value) shows restricted diffusion in the lesion; (D) Color ADC map. ADC value of oncocytoma is 2.6010C3 mm2/s. RCC has lower ADC values than oncocytoma. Abbreviations: RCC, renal cell carcinoma; ADC, apparent-diffusion-coefficient; ROI, region of interest; DWI, diffusion-weighted-imaging. Adrenal masses are commonly detected on computed tomography (CT). Chemical shift MRI is useful in differentiating adenoma from nonadenoma. There is limited study related to usefulness of DWI in TMP 269 price malignant tumors. Usually malignant tumors show bright signal on DWIs, and ADC values of malignant tumors are less than benign TMP 269 price tumors TMP 269 price ((32) evaluated the diagnostic utility of DWI for the analysis of adrenal tumors. They discovered no difference TMP 269 price in ADC ideals between adenomas and metastatic tumors. Nevertheless, pheochromoacytomas got higher mean ADC worth weighed against those of TMP 269 price adenomas and metastasis. Open up in another window Figure 11 Large remaining surrenal carcinoma tested histopathologically. (A).