BACKGROUND: Melanoma is apparently a malignant disease, whose development can be potentiated by different drug groups. patient also reported about the presence of a pigmented lesion in the abdominal area, which occurred 5-6 years ago, before the onset of cardiac therapy. According to him, there was a change in the colour and size of the lesion within the framework of cardiac therapy (from 1.5-2 years). Innovative one step melanoma surgery was performed, and the lesion was radically removed with a 1 cm operational safety margin in all directions within one operative session. The subsequent histological verification found the presence of thin melanoma. CONCLUSION: Drug-induced melanoma turned out to be a problem of significant importance. The group of angiotensin receptor blockers should be investigated more thoroughly and in detail on the probability of potentiating carcinogenesis. We describe an interesting case showing the progression of pigment lesion to melanoma as a possible result of irbesartan therapy, i.e. we share a theory that differs from that of drug-induced de novo melanomas. It will not really become overlooked the actual fact that another utilized drug-Aspirin broadly, will probably potentiate the introduction of melanoma also. Furthermore, the situation can be indicative of the usage of one stage melanoma surgery inside a melanoma individual having a thickness significantly less than 1 mm. solid course=”kwd-title” Keywords: Losartan, Valsartan, Melanoma, Medical procedures procarcinogenic impact Intro The real amount of research, relating to which different sets PXD101 novel inhibtior of antihypertensive medicines will probably potentiate the introduction of melanoma, increases [1] significantly, [2], [3]. Based on the books, angiotensin receptor blockers Tcf4 (ARBs), that are utilized as antihypertensive medicines broadly, carry an elevated risk of developing a cancer [4]. The latest data suggest that the occurrence of cutaneous cancer, including cutaneous melanoma, is also associated with this group of drugs [2], [5]. Experimental in vitro data show that losartan (ARB) stimulates cell adhesion and invasion of human melanoma cells [3]. Case report We present a 45-year-old man in good general condition and concomitant arterial hypertension, controlled through medication with Aspirin 100 mg (0-0-1) and Irbesartan/ Hydrochlorothiazide 150 mg/12.5 mg (1-0-0). The patient was hospitalised at the clinic around the occasion of worsening, for several months, of psoriasis vulgaris, diagnosed from 20 years. During the dermatological examination, despite the psoriatic skin changes, in the area of regio abdominalis dextra, was visualised as obtaining a hyperpigmented macula with uneven pigmentation and uneven edges (Physique 1a and ?and1b).1b). According to the patient, the pigmented lesion appeared 5-6 years ago. Medication therapy with Aspirin and Irbesartan/Hydrochlorothiazide dates from 1.5-2 years. According to anamnestic data, within the framework of cardiac therapy, the patient observed a change in the colour and size of PXD101 novel inhibtior the lesion. Clinically and dermatoscopically, the pigmented macula met the requirements for a malignant melanocytic lesion. Also, clinical and dermatoscopic data spoke in favour of melanoma less than 1 mm thick. Based on these data, one step melanoma surgery (OSMS) was performed. The lesion was removed by elliptical excision, under local anaesthesia, with a surgical field of 1 1 cm in all directions (Physique 1b and ?and1c).1c). The surgical defect was closed by a single interrupted sutures (Physique 1d). Histological examination confirmed the diagnosis: superficial malignant melanoma, Clark II level, Breslows thickness below 1 mm, no ulceration, low mitotic activity, well-expressed lymphocytic stromal reaction, clear resection lines. The staging was performed according to which it PXD101 novel inhibtior was found to be melanoma Stage I (T1aN0M0). Open in a separate window Physique 1 a) Clinical picture of primary cutaneous melanoma located in regio abdominalis dextra with uneven pigmentation; b) Outlining.