Colonic enterocytes, like many epithelial cells in vivo, are polarized with

Colonic enterocytes, like many epithelial cells in vivo, are polarized with functionally distinct apical and basolateral membrane domains. alpha (TGF-) or an EGFR neutralizing antibody also resulted in a dose-dependent stimulation or attenuation, respectively, of DNA replication. However, no mitogenic response was observed when these agents were added to the apical compartment or to confluent cells cultured on plastic. We conclude that amphiregulin acts as an autocrine Prostaglandin E1 distributor growth factor in HCA-7 and Caco-2 cells, Prostaglandin E1 distributor and EGFR ligand-induced proliferation is influenced by cellular polarity. ? 1999 Cancer Research Campaign strong class=”kwd-title” Prostaglandin E1 distributor Keywords: EGFR, polarized cells, colon cancer cell lines, ligand and proliferation PLA2B Full Text The Full Text of this article is available as a PDF (477K). Selected.