The nuclear and oncogenic BCL-3 protein activates or represses gene transcription when bound to NF-κB proteins p50 and p52 yet the molecules that specifically interact with BCL-3 and drive BCL-3-mediated effects on gene expression remain largely uncharacterized. of an oncogenic IκB protein and they establish a functional link between the E3 ligase TBLR1 and NF-κB.… Continue reading The nuclear and oncogenic BCL-3 protein activates or represses gene transcription