The HIV protein Nef is considered to mediate immune evasion and promote viral persistence partly by down-regulating major histocompatibility complex class I protein (MHC-I or HLA-I) from the cell surface. was similarly avid for native HLA-I and recombinant HLA-I A2 at the PM. Nef binding to HLA-I at the PM was sensitive to specific inhibition… Continue reading The HIV protein Nef is considered to mediate immune evasion and