The extracellular space of the brain contains -aminobutyric acid (GABA) that activates extrasynaptic GABAA receptors mediating tonic inhibition. 1986; Lerma 1986; Ding 1998; Kuntz 2004). Extra- and peri-synaptic GABAA receptors (GABAARs) are in a NES favored position to be activated by the low levels of ambient GABA, due to their high GABA affinity in contrast… Continue reading The extracellular space of the brain contains -aminobutyric acid (GABA) that