Recombinational repair processes multiple types of DNA lesions. unlike those missing PCNA poly-ubiquitination, are not sensitive to replication stress, redundant or alternative pathways must exist that can recognize the PCNA poly-ubiquitination signal. In this regard, the human ZRANB3 helicase has been shown to bind poly-ubiquitinated PCNA and lead to replication fork regression, an event that… Continue reading Recombinational repair processes multiple types of DNA lesions. unlike those missing