The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. E3 and E4 regions do BYL719 not induce appreciable expansion of vector-specific CD4+ T cells. Replication-defective adenoviruses (rAd) have been engineered to… Continue reading The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells