Supplementary MaterialsSupplemental Table 1. casein-kinase-2-mediated phosphorylation of Beclin-1, preventing Rabbit polyclonal to HSD17B13 Beclin-1CVps34 interaction and subsequent autophagosome assembly. Thus, CTSB-mediated degradation of Dab2 allows Beclin-1CVps34 induction of autophagy, whereas sustained Dab2 expression prevents autophagy and promotes apoptosis by stabilizing the pro-apoptotic Bim protein. studies suggest that Dab2-mediated regulation of autophagy modulates chemotherapeutic resistance and… Continue reading Supplementary MaterialsSupplemental Table 1. casein-kinase-2-mediated phosphorylation of Beclin-1, preventing Rabbit