Progression of chronic myeloid leukemia, marked from the oncogenic mutation, is tightly associated with an alteration of the p53 pathway. MDM2 in the KBM5 and K562 cells, it resulted in proteasome-independent MDM2 degradation in p53-expressing KBM5 cells, however, not in p53-null K562 cells. Consequently, the present study suggested that p53 causes the butein-mediated apoptosis of… Continue reading Progression of chronic myeloid leukemia, marked from the oncogenic mutation, is