Supplementary MaterialsS1 Fig: Lack of Ykt6 leads to accumulation of autophagosomes. using the lysosomal marker Light1-GFP. Inset displays the boxed area enlarged. (B) The autophagic marker 3xmCherry-Atg8a displays intensive colocalization (yellowish arrowheads) using the lysosomal protease Cathepsin-L in GFP+ control cells. On the other hand, there is absolutely no overlap between both of these markers… Continue reading Supplementary MaterialsS1 Fig: Lack of Ykt6 leads to accumulation of autophagosomes.
Tag: Rabbit Polyclonal to ETV6
In a substantial proportion of individuals with chronic myeloid leukemia, resistance
In a substantial proportion of individuals with chronic myeloid leukemia, resistance to BCR-ABL tyrosine kinase inhibitors develops because of acquisition of kinase domain mutations and insensitivity of leukemia stem cells to tyrosine kinase inhibitors. who usually do not respond well to tyrosine kinase inhibitors. oncogene. Pathologically, CML individuals develop granulocytosis and splenomegaly. CML frequently begins… Continue reading In a substantial proportion of individuals with chronic myeloid leukemia, resistance