The functional HIV-1 envelope glycoprotein (Env) trimer the target of anti-HIV-1 neutralizing antibodies (Abs) is innately labile and coexists with nonnative types of Env. could withstand high temperature denaturants and various other destabilizing circumstances. Seven mutations in Env had been connected with elevated trimer stability mainly in the heptad repeat regions of gp41 but also… Continue reading The functional HIV-1 envelope glycoprotein (Env) trimer the target of anti-HIV-1