Anaplastic lymphoma kinase-positive (ALK+) anaplastic huge cell lymphoma (ALCL) can be an intense T-cell non-Hodgkin lymphoma seen as a the t(2;5) leading to overexpression of NPM-ALK which may activate the phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR pathway leading to cell routine and apoptosis deregulation. Knockdown of JUNB and CJUN in ALK+ ALCL cell lines downregulated mRNA and promoter activity… Continue reading Anaplastic lymphoma kinase-positive (ALK+) anaplastic huge cell lymphoma (ALCL) can be
Tag: Pseudoginsenoside-RT5
Tubulin and warmth shock protein 27 (Hsp27) are well-characterized molecular targets
Tubulin and warmth shock protein 27 (Hsp27) are well-characterized molecular targets for anti-cancer drug development. compounds for tubulin. The results revealed several structural moieties of the lead compounds that are critical for Hsp27 inhibition. The modification of these structural fragments eliminated Hsp27 inhibition but did not harm tubulin-targeting effects of the compounds. This result further… Continue reading Tubulin and warmth shock protein 27 (Hsp27) are well-characterized molecular targets