Supplementary Materials SUPPLEMENTARY DATA supp_44_21_10454__index. KO cells, it remains unclear whether pri-miRNA digesting is the primary function of c-Drosha. We determined two novel in-frame Drosha isoforms generated by substitute splicing in both HeLa and HEK293T cells. One isoform loses the putative nuclear localization signal, generating c-Drosha. Further analysis indicated that the c-Drosha isoform is abundant… Continue reading Supplementary Materials SUPPLEMENTARY DATA supp_44_21_10454__index. KO cells, it remains unclear whether