In fibrotic liver connective tissue development factor (CTGF) is continually expressed in turned on hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix creation. signaling molecule to mediate CTGF appearance. This technique requires gene transcription and it is modulated by MEK1/2 JNK and PI3K pathways additionally. Cell-specific knockdown of Smad3 partly… Continue reading In fibrotic liver connective tissue development factor (CTGF) is continually expressed