Mutations in the catalytic subunit of phosphoinositide 3-kinase (and other PI3K-AKT pathway elements have been connected with tumor and a broad spectrum of mind and body overgrowth. Fauser et al., 2015; Fauser, 2006). Conditional mouse alleles for the and hotspot mutations have already been generated to review tumor development and assess anti-cancer actions of pathway… Continue reading Mutations in the catalytic subunit of phosphoinositide 3-kinase (and other PI3K-AKT