and so are putative oncogenes that modulate stem cell pluripotency and are likely involved in leukemogenesis. reduced Bmi-1 expression significantly. Reducing SALL4 appearance by siRNA in the HL-60 leukemia cell range also leads to significant down-regulation of Bmi-1. Furthermore Bmi-1 appearance is certainly up-regulated in transgenic mice that constitutively overexpress individual SALL4 as well as… Continue reading and so are putative oncogenes that modulate stem cell pluripotency and