Destabilized mutants of the tumor suppressor p53 are inactivated by self-aggregation in a considerable number of tumors and may also coaggregate with and inactivate WT p53 and family users. Accordingly, T9 and H5 are highly aggregation-prone areas, adopted by H10, H8, and H1 areas. Many areas within the p53 sequence are very aggregation-prone and can… Continue reading Destabilized mutants of the tumor suppressor p53 are inactivated by self-aggregation