Defects in chromosome synapsis and/or meiotic recombination activate a surveillance mechanism that blocks meiotic cell cycle progression to prevent anomalous chromosome segregation and formation of aberrant gametes. unrepaired DNA double-strand breaks accumulate, leading also to activation of the meiotic recombination checkpoint (Lydall and mutants are useful genetic tools to elicit the meiotic recombination checkpoint response,… Continue reading Defects in chromosome synapsis and/or meiotic recombination activate a surveillance mechanism