Differentiated somatic cells could be reprogrammed into totipotent embryos through somatic cell nuclear transfer. H3 lysine 9 trimethylation demethylase features as a hurdle for two-cell arrest of cloned embryos. Furthermore we found that inactivation of another histone demethylase Kdm5b makes up about the arrest of cloned embryos on the four-cell stage through single-cell evaluation. Co-injection… Continue reading Differentiated somatic cells could be reprogrammed into totipotent embryos through somatic