The Bone Morphogenetic Protein antagonist Gremlin 2 (Grem2) is required for atrial differentiation and establishment of cardiac rhythm during embryonic development. Gremlin subfamily of BMP antagonists. Grem2 pro-atrial differentiation activity is conveyed by non-canonical BMP signaling through phosphorylation of JNK and IL17RA antibody can be reversed by specific JNK inhibitors but not by dorsomorphin an… Continue reading The Bone Morphogenetic Protein antagonist Gremlin 2 (Grem2) is required for