Covalent modification of the proteome by SUMO is critical for genetic stability and cell growth. the PIAS family SUMO E3 ligase Pli1. Consequently SUMO chain-modified Pli1 is targeted for proteasomal degradation by the concerted action of a SUMO-targeted ubiquitin ligase (STUbL) and Cdc48-Ufd1-Npl4. Pli1 degradation causes the serious SUMO pathway problems and connected centromere dysfunction… Continue reading Covalent modification of the proteome by SUMO is critical for genetic